Regulatory interactions for iron ...

2012-1-19 · In System Biology, iterations of wet-lab experiments followed by modelling approaches and model-inspired experiments describe a cyclic workflow. This approach is especially useful for the inference of gene regulatory networks based on high-throughput gene expression data. Experiments can verify or falsify the predicted interactions allowing further …

Metabolism, HDACs, and HDAC Inhibitors: A Systems …

1989-11-11 · Histone deacetylases (HDACs) are epigenetic enzymes that play a central role in gene regulation and are sensitive to the metabolic state of the cell. The cross talk between metabolism and histone acetylation impacts numerous biological processes including development and immune function. HDAC inhibitors are being explored for treating cancers, …

Toward a systems biology map of iron metabolism

2009-4-28 · The present study set out to provide researchers with a systems biology map of iron metabolism that would allow scientists to investigate changes in …

A Systems Biology Approach to Study Metabolic …

A Systems Biology Approach to Study Metabolic Syndrome. Editors: Oresic, Matej, Vidal-Puig, Antonio (Eds.) Free Preview. A comprehensive account of using Systems Biology to study Metabolic Syndrome (MetS) The applications of selected technologies and models to tackle specific pathophysiologically relevant aspects of metabolic syndrome. An ...

A systems biology approach to understand gut microbiota ...

2020-7-8 · Systems biology models can provide an advanced reconstruction of individuals'' metabolism at different organ levels in patients with morbid obesity. They could provide a valuable tool in predicting individuals'' outcomes of bariatric surgery and hereby develop a personalized medicine approach for this disease.

Toward A Systems Biology Map Of Iron Metabolism ...

2009-4-29 · Toward A Systems Biology Map Of Iron Metabolism Date: April 29, 2009 Source: ia Tech Summary: Scientists have taken the first steps toward constructing a systems biology map of iron metabolism.

A Systems Biology Approach Reveals Converging …

2016-7-1 · Conclusions: Our systems biology approach allowed identification of converging pathways leading to activation of common downstream targets. To our knowledge, this is the first study to propose an integrated global set of step-by-step molecular mechanisms for a combination of three common POPs using a systems biology approach, which may link POP exposure to …

A Systems Biology Approach to Cancer Metabolism ...

Cancer cells have been known for some time to have very different metabolismas compared to that of normal non proliferating cells. As metabolism is involvedin almost every aspect of cell function, there has been a recent resurgence ofinterest in inhibiting cancer metabolism as a therapeutic strategy. Inhibitors thatspecifically target altered metabolic components in cancer …

A SYSTEM BIOLOGY APPROACH TO ELUCIDATING THE …

2020-12-4 · The aim of this research project is to elucidate the biosynthetic architecture and evolution of terpenoid benzoquinones in plants. Although often perceived as ''exotic'' compounds, terpenoid quinones are actually vital electron and proton carriers in biological membranes. In other words, prenylated quinones are at the core of the energy production machinery of the cell.

"A Systems Biology Approach to Iron Metabolism" by ...

Iron is critical to the survival of almost all living organisms. However, inappropriately low or high levels of iron are detrimental and contribute to a wide range of diseases. Recent advances in the study of iron metabolism have revealed multiple intricate pathways that are essential to the maintenance of iron homeostasis. Further, iron regulation involves processes at several …

A Systems Biology Approach to Understanding the ...

2019-9-9 · A Systems Biology Approach to Understanding the Pathophysiology of High-Grade Serous Ovarian Cancer: Focus on Iron and Fatty Acid Metabolism Anna Konstorum,1 Miranda L. Lynch,2 Suzy V. Torti,3 Frank M. Torti,3 and Reinhard C. Laubenbacher1,4 Abstract Ovarian cancer (OVC) is the most lethal of the gynecological malignancies, with diagnosis often ...

A systems biology approach to iron metabolism.

2014-1-1 · A Systems Biology Approach to Iron Metabolism. The complexity of iron regulation in mammals makes a systems biology approach crucial, with its enabling technology of computational models based on a mathematical description of …

A Systems Biology Approach to Iron Metabolism | …

2014-12-6 · This complexity makes a systems biology approach crucial, with its enabling technology of computational models based on a mathematical description of regulatory systems. Systems biology may represent a new strategy for understanding imbalances in iron metabolism and their underlying causes.

A Systems Biology Approach to Iron Metabolism

A Systems Biology Approach to Iron Metabolism - CORE Reader

UiS Brage: A systems biology approach to cellular ...

A systems biology approach to cellular homeostasis, volume changes and regulation of metabolism by Gunhild Fjeld, Stavanger : University of Stavanger, 2020 (PhD thesis UiS, no. 509) Abstract Cells need to respond to a vast range of different disturbances and changes over small and large time scales.

Applying a systems approach to thyroid physiology: …

2017-6-1 · Applying a systems approach to thyroid physiology: Looking at the whole with a mitochondrial perspective instead of judging single TSH values or why we should know more about mitochondria to understand metabolism ... i.e. how to reach a concept of systems biology . ... Thyroid can also influence iron metabolism by modulating the interaction ...

Metabolic reconstruction of setaria italica: A systems ...

2021-11-9 · Here we chose foxtail millet (Setaria italica), as a C 4 model plant and developed protocols to perform systems biology studies. As part of the systems approach, we have developed and used a genome-scale metabolic reconstruction in combination with the use of multi-omics technologies to gain more insights into the metabolism of S. italica. mRNA ...

A Systems Biology Approach to Understanding the ...

A Systems Biology Approach to Understanding the Pathophysiology of High-Grade Serous Ovarian Cancer: Focus on Iron and Fatty Acid Metabolism OMICS . 2018 Jul;22(7):502-513. doi: 10.1089/omi.2018.0060.

Mining the Unknown: A Systems Approach to Metabolite ...

2012-10-18 · Author Summary Genome-wide association studies on metabolomics data have demonstrated that genetic variation in metabolic enzymes and transporters leads to concentration changes in the respective metabolite levels. The conventional goal of these studies is the detection of novel interactions between the genome and the metabolic system, providing …

Effects of abiotic stress on plants: a systems biology ...

2011-11-17 · The natural environment for plants is composed of a complex set of abiotic stresses and biotic stresses. Plant responses to these stresses are equally complex. Systems biology approaches facilitate a multi-targeted approach by allowing one to identify regulatory hubs in complex networks. Systems biology takes the molecular parts (transcripts, proteins and …

British Library EThOS: A systems biology approach to ...

A systems biology approach to cancer metabolism Author: Wright Muelas, Marina ISNI: 0000 0004 5372 5478 Awarding Body: University of Manchester Current Institution: University of Manchester Date of Award: 2016 Availability of Full Text: Access from EThOS: ...

Genome‐scale modeling of human metabolism – a …

2013-4-24 · Genome‐scale modeling of human metabolism – a systems biology approach. Adil Mardinoglu. Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden. Search for more papers by this author. Francesco Gatto.

A Systems Biology Approach to Iron Metabolism | Request …

Request PDF | A Systems Biology Approach to Iron Metabolism | Iron is critical to the survival of almost all living organisms. However, inappropriately low or high levels of iron are detrimental ...

[PDF] Basic Understanding of Iron Metabolism | Semantic ...

Iron is critical for almost all living organisms because it serves as a cofactor for many proteins and enzymes necessary for oxygen and energy metabolism. Disruption of iron homeostasis is associated with a wide range of diseases. Thus mammals have developed sophisticated mechanisms to maintain optimal range of iron concentration. Iron regulation involves …

A Systems Biology Approach to Understanding the ...

2009-4-29 · Toward A Systems Biology Map Of Iron Metabolism Date: April 29, 2009 Source: ia Tech Summary: Scientists have taken the first steps toward constructing a systems biology map of iron metabolism.

Cell Quizzes & Trivia A Systems Biology Approach to Iron ...

2021-11-28 · A Systems Biology Approach to Iron Metabolism Iron is required for oxygen transport, energy production, DNA synthesis and cellular respiration. Accordingly, inappropriately ... Ecological and commercial importance Test your skills on these questions and more in this quiz that''s all about biology.

A Systems Biology Approach to Study Metabolic …

A Systems Biology Approach to Study Metabolic Syndrome. Editors (view affiliations) Matej Orešič; Antonio Vidal-Puig; A comprehensive account of using Systems Biology to study Metabolic Syndrome (MetS) The applications of selected technologies and models to tackle specific pathophysiologically relevant aspects of metabolic syndrome.

A Systems Biology Approach to Iron Metabolism

2021-10-25 · Introduction. Dysregulation of iron metabolism plays a role in a wide range of diseases [], and understanding this role is crucial in the search for therapeutics.Fortunately, over the last decade, some key mechanisms involved in iron regulation have been uncovered, and a more complete picture of iron regulation is starting to emerge [] plicating the matter, …

A Systems Biology Approach to Iron Metabolism

2021-8-9 · A Systems Biology Approach to Iron Metabolism J. Chifman1, R. Laubenbacher2, and S.V. Torti3,* 1Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem NC 27157 USA 2Center for Quantitative Medicine, University of Connecticut Health Center, Farmington CT 06030 USA 3Department of Molecular Biology and Biophysics, University of …

(PDF) A Systems Biology Approach to Understanding the ...

A Systems Biology Approach to Understanding the Pathophysiology of High-Grade Serous Ovarian Cancer: Focus on Iron and Fatty Acid Metabolism July 2018 Omics: a Journal of Integrative Biology 22(7 ...

"A Systems Biology Approach To Elucidating The …

2016-11-18 · Gilles Basset Associate Professor, Plant Molecular and Cellular Biology Program, University of Florida Research in our laboratory focuses on the biosynthesis of prenylated quinones that function as vital electron and proton carriers for photosynthesis and respiration. Historically, this area of metabolism has been difficult to investigate, for it involves unstable …

Scientists are constructing a biology map of iron metabolism

2009-4-28 · The systems biology map was subsequently used to construct iron networks for specific types of cells that are known to be critical for iron metabolism. Mathematical approaches like the ones described in this study may prove useful in understanding the interactions between different iron-dependent species, identifying key regulatory points ...